重症手足口病与儿童生长发育的相关性

Relationship between the status of severe hand-foot-mouth disease infection and the development of children

目的探讨儿童生长发育与重症手足口病的相关性。方法采用整群随机抽样的方法,调查2010～2012年期间龙岗区发生的0～72月龄手足口病重症病例42例和门诊病例83例,计算研究对象的身高、体重标准百分位水平,采用WHO推荐的儿童生长发育标准(2007版),评价研究对象的发育状况。结果两组年龄别身高标准百分位水平差异没有统计学意义(t=-0.58,P=0.56),但年龄别体重标准百分位水平存在统计学差异(t=-3.23,P=0.00);两组儿童的低体重情况的构成比不同,差异有统计学意义(χ2=4.07,P=0.04);两组儿童的生长发育迟缓及消瘦情况的构成比相同,差异没有统计学意义(生长发育迟缓:χ2=1.08,P=0.30;消瘦:χ2=1.04,P=0.75)。结论重症手足口病的发生与儿童自身的近期营养状况有关,对于重症手足口病的防治可能可以从营养学的角度入手。

Objective To analyze the relationship between severe hand-foot-mouth disease infection and the development of children. Methods Using cluster random sampling methods, the 42 infants aged 0-72 months with severe hand-foot-mouth disease （HFMD） in observation group and 83 outpatients in control group in Baoan District of Shenzhen city in 2010-2012 were surveyed and the relationship between severe HFMD infection and the development of the children affected was analyzed based on WHO child growth standards （2007 Edition）. Results No significant differences in height was observed in standardized percentile level of height for age in two group no statistics differences （t=-0.58,P=0.56）, but statistically significant differences in weight for age of standardized percentile level of the group were noticed（t=-3.23,P=0.00）; The proportion of low weight infants in the two groups showed statistical differences （χ2=4.07,P=0.04）. No significant differences were observed in slow growth （χ2=1.08,P=0.30） and marasmus（χ2=1.04,P=0.75） was found.Conclusions Severe hand-foot-mouth disease associated with the nutritional status of children, for the prevention and treatment of severe hand-foot-mouth disease may be able to start from a nutrition perspective.