补脾固活汤对女性压力性尿失禁的影响

The influence of Bupi-Guhuo decoction on female stress urinary incontinence

目的 观察补脾固涩活血法对Ⅰ、Ⅱ度女性压力性尿失禁的影响.方法 选择2011年12月至2012年10月在中国中医科学院西苑医院泌尿外科门诊就诊的女性压力性尿失禁患者70例,按照随机数字表法将患者随机分为两组各35例,治疗组服用补脾固活汤治疗,2次/d,1袋/次.对照组采用盆底肌训练疗法治疗.两组均治疗4周后观察疗效.结果①ICS-Q-SF评分与尿失禁量比较：治疗后2周两组ICS-Q-SF评分与尿失禁量[治疗组分别为（6.42±0.79）分、（8.85±1.07）g,对照组分别为（6.81±0.91）分、（9.35±1.23）g]均较同组治疗前[治疗组分别为（7.73±1.52）分、（12.92±2.08）g,对照组分别为（7.71±1.48）分、（13.28±2.43）g]明显改善（P＜0.01）；治疗后4周[治疗组分别为（2.68±0.91）分、（2.62±1.08）g,对照组分别为（6.25±0.81）分、（8.02±1.32）g]与同组治疗后2周比较,治疗组差异有统计学意义（P＜0.01）,对照组则无明显变化（P＞0.05）.治疗组治疗后2周、4周与对照组同时间段比较,差异有统计学意义（P＜0.05或0.01）.②临床疗效比较：治疗后治疗组总有效率为67.7％ （21/31）,对照组为37.0％ （10/27）,两组总有效率比较,差异有显著性意义（P=0.000,P＜0.01）.结论 补脾固活汤疗效明显优于盆底肌肉训练疗法,且存在时效关系.

Objective To observe the effects of Bupi-Guhuo decoction in treating astringent Ⅰ,Ⅱ degree of female stress urinary incontinence.Methods 70 Women patients with stress urinary incontinence in outpatient of urology of Xiyuan Hospital of CACMS from December 2012 to October 2011 were randomly divided into a treatment group and a control group,with 35 cases in each group.The treatment group was treated with Bupi-Guhuo decoction,twice daily,1package per time; while the patients in the control group were treated with pelvic floor muscle training therapy.Both groups were treated for 4 weeks.Results The score of ICS-Q-SF and the amount of urinary incontinence comparison：2 weeks after treatment [the treatment group was （6.42～0.79） and （8.85～ 1.07） g respectively; the control group was （6.81～0.91） and （9.35～ 1.23） g respectively].Both groups had obvious improvement than before the treatment [the treatment group （7.73 ～ 1.52） and （12.92 ～2.08） g respectively,the control group was （7.71～ 1.48）and （13.28～2.43） g respectively] （P〈0.01）.4 weeks after the treatment [treatment group was（2.68～0.91）and（2.62～1.08） g respectively,the control group was （6.25～0.81） and （8.02～ 1.32）g respectively].Compared with the effects of 2 weeks after treatment,the difference was statistically significant （P〈0.01） in the treatment group,while with no significant change （P〉0.05） in the control group.At the 2 weeks,4 weeks treatment,the effects in the treatment group and the control group had statistical difference （P〈0.05 or 0.01）.（②）Clinical curative effect comparison：After treatment,the total effective rate was 67.7% （21/31） in treatment group and 37.0% （10/27） in the control group,showing significant difference （P=0.000,P〈0.01）.Conclusion Bupi-Guhuo decoction had better therapeutic effects than pelvic floor muscle training in the treatment of female Ⅰ,Ⅱ degree of stress urinary incontinence,also with a time-effect relationship.