盐酸吡格列酮治疗高血压合并2型糖尿病的临床研究

Efficacy of Pioglitazone Hydrochloride in the Treatment of Patients with Hypertension and Diabetes

目的探讨盐酸吡格列酮联合厄贝沙坦治疗高血压合并2型糖尿病的临床疗效。方法将100例符合研究标准的高血压合并2型糖尿病患者随机分为观察组和对照组,每组50例。在降血糖治疗的同时,对照组给予厄贝沙坦150 mg口服,每日1次;观察组在对照组的基础上给予盐酸吡格列酮15 mg口服,每日1次,治疗12 W后对两组的疗效进行比较分析。结果观察组血压下降的总有效率为92.00%,对照组为76.00%,两组差异有统计学意义(P<0.05)。两组患者的SBP,DBP,FPG,2hPG,HbA1c均比治疗前明显降低(P<0.05),但观察组降低更显著(P<0.01)。结论盐酸吡格列酮能明显降低患者的血糖和血压水平,联合厄贝沙坦治疗高血压合并2型糖尿病安全可靠、疗效显著,血压控制平稳。

Objective To study the clinical effect of pioglitazone hydrochloride in the treatment of patients with hypertension and diabetes. Methods 100 patients with hypertension and diabetes were randomly divided into the observation group and control group, with 50 cases in each group. The two groups were given conventional treatment. The control group was given 150 mg ofirbesartan tablets, once a day. The observation group was given 15 mg pioglitazone hydrochloride on the base of control group, once a day. Both groups were treated for 3 months. The clinical efficacy was compared. Results The total effective rate of observation group was 92.00%, significantly higher than 76.00% of control group （P〈0.05）. The SBP, DBP, FPG, 2hPG, HbAlc of two groups after treatment were significantly decreased compared with those before the treatment （P〈0.05）, but the observation group decreased more significantly （P 〈0.01）. Conclusions The clinical effect of pioglitazone hydrochloride in the treatment of patients with hypertension and diabetes is satisfactory and safe.