米索前列醇不同给药方法在产后出血预防中的效果研究

Effect Analysis of Different Drug Ways of Misoprostol in the Prevention of Postpartum Hemorrhage

目的探讨不同给药方法下米索前列醇在产后出血预防中的临床效果,探索最佳给药方法。方法以我院2011年6月至2012年6月间来院生产的200例产妇为研究对象,随机分为直肠给药组100例和口服给药组100例,两组产妇均使用米索前列醇预防产后出血,收集并统计产妇出血量、子宫收缩和不良反应情况,并就研究指标进行对比分析。结果直肠给药组产妇产后2 h和24 h出血量少于口服给药组(P<0.05),子宫收缩效果优于口服给药组(P<0.05),不良反应均较口服给药组少且症状轻微,但差异不具有统计学意义(P>0.05)。结论米索前列醇直肠给药方式预防产后出血效果较好,子宫收缩情况和产妇出血量均好于口服给药组产妇,安全可靠,可推广应用。

Objective To explore the clinical effect of different drug ways of misoprostol in the prevention of postpartum hemorrhage, so as to provide the best way of drug administration. Methods 200 puerpera in our hospital from June 2011 to June 2012 were selected as the research objects and randomly divided into the rectal administration group and the oral administration group, with 100 cases in each group. Both groups were treated with misoprostol with different drug ways （rectal administration vs. oral administration）. The maternal bleeding, uterine contraction and adverse reaction were recorded and compared between two groups. Results The maternal bleeding 2 hours and 24 hours of the rectal administration group were less than that of oral administration group （P 〈0.05）. The uterine contraction effect of the rectal administration group were better than that of oral administration group （P 〈0.05）. The incidence of adverse reactions of the rectal administration group was less than that of the oral administration group, but the difference between two group was not statistically significant （P〉0.05）. Conclusions Misoprostol for rectal administration has good clinical effect in the prevention of postpartum hemorrhage. It is superior to oral administration in uterine contraction and adverse reaction. It is worthy of clinical application.