新疆哈萨克族原发性高血压患者血清尿酸水平的影响因素分析

Influencing factors for serum level of uric acid in Xinjiang Kazakh patients with essential hypertension

目的：探讨新疆哈萨克族原发性高血压（EH）患者血清尿酸（UA）水平的影响因素。方法：纳入我院2009年1月至2012年12月所有首次诊断为EH并未行降压治疗的新疆哈萨克族住院患者696例，按入院血压水平分为轻度高血压组（336例）和中重度高血压组（360例），检测所有患者的l临床相关指标，分析新疆哈萨克族EH患者血清uA水平影响因素。结果：（1）与轻度高血压组比较，中重度高血压组血清UA[（269．08±86．49）mmol／L比（311．53±97．66）mmol／L]、甘油三酯[（1．36±0．66）mmol／L比（1．72±1．05）mmol／L]水平明显升高（P〈0．05）；（2）Pearson相关性分析显示血清UA水平与BMI、收缩压、舒张压、血清尿素氮、血清肌酐、甘油三酯水平正相关（r=0．17～0．29，P均〈0．05）；（3）多元线性回归分析校正BMI，收缩压，血清尿素氮，血清肌酐，空腹血糖，总胆固醇等因素后，舒张压（B=1．66，P〈0．05）、甘油三酯水平（B=19．34，P〈0．05）均进入方程。结论：新疆哈萨克族原发性高血压患者的血压水平是血清尿酸水平的一个独立影响因素。

Objective： To explore influencing factors for serum level of uric acid （UA） in Xinjiang Kazakh patients with essential hypertension （EH）. Methods： A total of 696 Xinjiang Kazakh inpatients, who were first diagnosed as EH and did not received antihypertensive therapy during Jan 2009 to Dec 2012 in our hospital, were enrolled. Ac-cording to blood pressure level at admission, they were divided into mild hypertension group （n = 336） and medium-severe hypertension group （n = 360）. Clinical relative indexes were measured, and influencing factors for serum level of UA were analyzed in Xinjiang Kazakh EH patients. Results： （1） Compared with mild hypertension group, there were significant increase in serum levels of UA [ （269.08 ± 86. 49） mmol/L vs. （311.53 ± 97.66） mmol/L] and tri-glyceride ETG, （1.36 ± 0.66） mmol/L vs. （1.72 ± 1.05） mmol/L] in medium-severe hypertension group, P〈0.05 both; （2） Pearson correlation analysis indicated that serum UA level was positively correlated with body mass index （BMI）, levels of systolic blood pressure （SBP）, diastolic blood pressure （DBP）, serum blood urea nitrogen （BUN）, serum creatinine （Cr） and TG （r = 0.17-0.29, P〈0.05 all） ; （3） After BMI, SBP, serum BUN, serum Cr, fast-ing blood glucose and total cholesterol were corrected, the DBP （B= 1.66, P〈0.05） and TG level （B=19.34, P〈0.05） entered the equation in multiple linear regression analysis. Conclusion： Blood pressure level is an independent influencing factor for serum level of uric acid in Xinjiang Kazakh patients with essential hypertension.