氯谷胺的合成

Synthesis of Loxiglumide

目的合成急性胰腺炎用药氯谷胺。方法以谷氨酸和3,4-二氯苯甲酸为起始原料,经缩合、酐化、胺解反应合成了氯谷胺。结果及结论工艺简单,条件温和,适于大规模生产。

Objective： To synthesize loxiglumide, a novel drug for acute pancreas inflammation. Methods With glutamic acid and 3,4-dichlorobenzoic acid as starting materials, loxiglumide was synthesized by condensation, anhydrization and aminolysis reactions. Results and Conclusion This route can be simple and easy controlled, and can be used in a large scale production of loxiglumide.