HCV相关性神经系统病变
摘要
HCV感染最常见且研究最透彻的肝外表现（extrahepatic manifestations，EHMs）是冷球蛋白（cryoglobulin，CG）血症，约17%～60%病例通常在疾病起始阶段会出现外周神经病，约6%病例存在中枢神经系统（central nervous system， CNS）受累。除导致血管损伤以外，CG也是颈动脉斑块形成的独立危险因素。其他EHMs如非霍奇金氏淋巴瘤、糖尿病、甲状腺疾患、风湿病等，也可累及神经系统。HCV具有嗜神经性，CNS内可检测出HCV RNA的复制模板及病毒蛋白，HCV可致脑部免疫应答激活及代谢改变[1]。亦如大多数EHMs，HCV相关性神经系统病变也具有免疫学或风湿病学特性。已报道的HCV相关性CNS及神经肌肉病变见表1。
出处
《中国肝脏病杂志（电子版）》
CAS
2013年第3期56-60,共5页
Chinese Journal of Liver Diseases：Electronic Version
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