先天性甲状腺功能减低症的发病率与季节及温度相关性研究

Correlation with season and temperature in the incidence of congenital hypothyroidism

目的了解安徽省先天性甲状腺功能减低症(congenital hypothyroidism,CH)发病率与季节、温度之间的关系,为降低CH发病率提供科学依据。方法通过对2001-2012年CH发病情况回顾性研究,采用Spearman相关分析来探讨发病率与环境温度之间的关系。结果在690例CH中,有34.78%分布在暖季,65.22%分布在冷季,冷季发病率高于暖季,差异有统计学意义(P<0.05)。月发病率与环境温度之间有一定相关性,男性患儿的相关性高于女性患儿。结论安徽省CH发病率存在与季节及温度相关性特征。

Objective To examine the seasonality of congenital hypothyroidism （CH） incidence and ifs correlation with ambient temperature in Anhui province. Method Retrospective study of CH disease in 2001-2012 to analyzed the corre- lation with temperature by using Spearman＇s correlation analysis. Results In the 690 cases of CH,it had 34.78 % distribu- tion in the warm season and the rest of 65.22% distribution in the cold season,CH incidence in cold season was higher than that in warm season. Consequently,the difference was statistically significant （P-〈0.05）. There was a certain correlation be tween the monthly incidence rate and environmental temperature. In the meantime,correlation between male group were sig- nificantly higher than that of female patients. Conclusion The CH incidence has certain characteristics,which has relevant to the change of the temperature and the season.