支气管哮喘患儿血清IL-17、ECP及IgE的水平测定及临床意义

Clinical significance of serum levels of IL-17,ECP,and IgE detection in children with bronchial asthma

目的探讨支气管哮喘患儿血清白介素17(IL-17)、嗜酸细胞阳离子蛋白(ECP)及免疫球蛋白E(IgE)水平与哮喘发生、发展的关系及相关性研究。方法对82例轻中度哮喘患儿血清IL-17、ECP及IgE水平检测,并与健康对照组的20例儿童进行比较分析。结果与对照组比较,哮喘组血清IL-17、ECP及IgE水平显著升高,差异有统计学意义(t=70.594、19.202、44.824,P均<0.01);与缓解组比较,急性发作组血清ECP、IgE水平显著升高,差异有统计学意义(P均<0.01),IL-17水平升高,但差异无明显统计学意义(P>0.05);哮喘组血清ECP与IgE呈正相关(r=0.337,P<0.01),IL-17与ECP、IgE之间无明显相关,但在急性发作组,IL-17与ECP、IgE呈正相关(r=0.314和0.325,P均<0.05)。结论 IL-17是一个复杂的细胞因子,参与介导哮喘的嗜酸粒细胞性炎症,ECP及IgE水平对哮喘病情判断及治疗具有重要临床意义。

Objective To study the clinical significance of detecting serum levels of IL-17, ECP and IgE in children with bronchial asthma（BA）. Method The serum levels of IL-17, ECP and IgE were detected in 82 children with light- midrange asthma and compared with those of 20 healthy children in the healthy control group. Results The serum levels of IL-17,ECP and IgE in the BA group were significantly higher than those in the healthy control group,there were signifi- cant differences（all P〈0.01）. The serum levels of ECP and IgE in the acute exacerbation group were significantly higher than those in the remission group（all P〈0. 01）, and the serum level of IL-17 in the acute exacerbation group was mildly higher than that in the remission group,but there were no significant differences （P〈0.05）. The serum level of ECP was actively correlated with the serum levels of IgE in children with asthma（r=0. 337 ,P〈0.01）. The serum level of IL-17 was no actively correlated with the serum level of ECP and IgE. But the serum levels of IL-17 was actively correlated with the se- rum level of ECP and IgE in the acute exacerbation group（r=0. 314 and 0. 325,P〈0.05）. Conclusions IL-17,as a com- plicated cytokine,is possibly involved in eosinophilic inflammation mediating asthma. Detecting the change of the serum level of ECP and IgE is of very important clinical value in detection and treatment of pathogenetic inflammation for children with bronchial asthma.