行气调神针刺疗法对缺血性卒中后抑郁模型大鼠行为学影响的研究

Influence of Xingqi Tiaoshen Acupuncture Therapy on Ethology of Post Stroke Depression Model Rats

目的:探讨行气调神针刺疗法对缺血性卒中后抑郁(PSD)模型大鼠行为学的影响。方法:将80只SD大鼠随机分为正常组、模型组、针刺组、氟西汀组4组。针刺组针刺大鼠双侧合谷穴、双侧太冲穴、人中穴。观察大鼠1%蔗糖水饮用量,进行敞箱实验、Morris水迷宫实验以及Zea Langa神经行为学评分。结果:与氟西汀组比较,治疗第42天针刺组大鼠垂直运动次数增加(P<0.05),Zea Langa神经行为学评分降低(P<0.05);Morris水迷宫实验第4天,针刺组大鼠学习能力提高(P<0.05)。结论:行气调神针刺疗法可以改善模型鼠缺血性卒中后抑郁。

Objective:To investigate the influence of Xingqi Tiaoshen acupuncture therapy on ethology of post stroke depression(PSD) model rats.Methods:80 SD rats were randomly divided into normal group,model group,acupuncture group,fluoxetine group.Rats in acupuncture group were acupunctured at hibateral Hegu points,hibateral Taichong points and Renzhong point.Drinking contents of 1%sucrose water of rats were observed.Open-field test,Morris water maze and Zea Langa neurobehavioral score were used.Results:Compared with fluoxetine group,at the 42^(th) day of treatment,times of vertical movement of rats in acupuncture group were increased(P<0.05),but Zea Langa neurobehavioral score was decreased(P<0.05).Compared with fluoxetine group,at the forth day of Morris water maze test,number of learning scores of rats in acupuncture group was enhanced(P<0.05).Conclusion:Xingqi Tiaoshen acupuncture therapy could improve depression status of PSD model rats.