氯吡格雷抵抗机制的研究进展及临床处理策略

Research Progress: Mechanisms and Intervention Strategies of Clopidogrel Resistance

冠心病患者尽管接受了标准的氯吡格雷治疗,但仍有一部分患者对氯吡咯雷表现为低反应甚至无反应,称为氯吡格雷抵抗.导致这种抵抗现象的可能原因包括患者个体的基因多态性和药物之间的相互作用等.临床处理的主要对策有提高氯吡格雷的给药剂量和采用新型药物等.笔者就现有的临床研究证据对氯吡格雷抵抗的定义、发生机制及临床干预策略进行了综述.

Despite the standard dose of clopidogrel used in treatment of the patients with coronary heart disease,many studies have found that some patients show low response even no response to clopidogrel,which is defined as clopidogrel resistance.In this paper,we explore the mechanism of clopidogrel resistance,and suspect that the clopidogrel resistance may be caused by the individual gene polymorphism,drug interactions and so on.The countermeasures to the clopidogrel resistance include increasing the clopidogrel dosage,use of new drugs,etc.The definition and triggering mechanism of the clopidogrel resistance are also reviewed in this report.