氟伏沙明合并森田疗法治疗难治性强迫症的疗效分析

Effects of Morita therapy combined with fluvoxamine in treatment of refractory obsessive-compulsive disorder

目的:探讨氟伏沙明合并森田疗法治疗难治性强迫症的疗效。方法:88例难治性强迫症患者随机分为两组,对照组单用氟伏沙明治疗,实验组用氟伏沙明合并森田疗法治疗,治疗12周,并随访6个月。分别于治疗前,治疗后第4、8、12周,6个月末用耶鲁布朗量表(Y-BOCS)评定疗效。结果:实验组有效率为90.9%,明显高于对照组的70.4%,有统计学差异(x2=3.21,P<0.05);与对照组相比,实验组的Y-BOCS减分更高,在12周末开始出现显著性差异,并持续至6个月末。结论:氟伏沙明合并森田疗法治疗难治性强迫症可提高有效率。

Objective：To investigate effects of Morita therapy combined with fluvoxamine in treatment of refractory obsessive- compulsive disorder （OCD）. Methods ：88 patients who met the CCMD-3 for OCD were involved for the twelve weeks study. All pa- tients were randomly divided into test group and control group, the cases in test group were treated with Morita therapy combined with fluvoxamine, whereas those in control group were treated only with fluvoxaminc. All of them were followed-up for 6 months. Moreover, the effects were evaluated with Yale-Brown Obsessive-Compulsive Scale（Y-BOCS） before and 4, 8, 12 weeks and 6 months after the treatment. Results： The effective rate of test group （90.9%） was higher than that of control group （70.4%）, and the difference was obvious （x2 =3.21, P〈0.05）. The percentage decrease on the Y-BOCS of test group was higher than that of control group, and the difference appeared 12 weeks after the treatment and lasted until 6 months. Conclusions： Morita therapy combined with fluvoxamine is optimal for OCD and can improve the effective rate.