依达拉奉对心肺复苏患者脑功能的作用

Effects of Edaravone on Cerebral Function in Cardiopulmonary Resuscitation Patients

目的:观察依达拉奉对心肺复苏患者脑功能的作用。方法:选择2010年8月-2012年12月55例恢复自主循环的心肺复苏患者作为研究对象,将其分为两组:E组在自主循环恢复后除采用常规的支持治疗外加用依达拉奉,C组则采用常规的支持治疗。所有患者均在自主循环恢复后即时复苏后即时、复苏后1、4、7 d分别进行格拉斯哥评分(GCS),同时观察患者的住院时间、病死率、多脏器损坏发生率等指标。结果:自主循环恢复即刻、1 d两组GSC比较差异无统计学意义(P>0.05),复苏后4、7 d的GCS较自主循环恢复即刻差异有统计学意义(P<0.05)。E组的住院时间、病死率多脏器损害发生率较C组显著较少(P<0.05)。结论:依达拉奉对心肺复苏患者脑功能的改善有显著作用,且可缩短患者住院时间,保护重要脏器功能,降低病死率,有助于改善预后。

Objective：To investigate the effects of edaravone on cerebral function in cardiopulmonary resuscitation patients.Method：Fifty-five patients undergoing restoration of spontaneous circulation （ROSC） from August 2010 to December 2012 were randomly divided into two groups：E group used routine supportive treatment and edaravone,C group used routine supportive treatment. Glasgow Coma Scale （GCS） was used at 0 h,24 h,4 d and 7 d after ROSC. Besides,length of stay in the hospital for survival,mortality and incidence of multiple organ dysfunction syndromes were observed.Result：GCS at 0 h,24 h fter ROSC showed no statistical difference （P〉0.05）,however,4 d and 7 d after ROSC showed a significant decrease in GCS as compared with 0 h after ROSC （P〈0.05）;length of stay in the hospital for survival,mortality and the incidence of multiple organ dysfunction syndrome were showed significant lower than those in C group（P〈0.05）. Conclusion：Edaravone is capable of improving cerebral function in cardiopulmonary resuscitation patients,and can shorten the length of stay in the hospital for survival,protect vital organ function and decrease the mortality in cardiopulmonary resuscitation patients.