恩诺沙星在鹅体内的药代动力学研究

Pharmacokinetics of enrofloxacin in geese

本文对恩诺沙星在鹅体内的药动学特征进行了研究,36只鹅随机分为2组,A组静脉注射恩诺沙星溶液;B组口服恩诺沙星溶液,给药剂量均为10mg/kg体重。数据采用DAS2.0进行分析。试验结果显示,静脉注射组多项药动学参数与口服组相比存在较显著差异,静脉注射组AUC约为口服组的1.3倍,在其体内清除率仅为口服组的3/5,但在体内消除却较快,平均驻留时间仅为口服组的7/10,结合恩诺沙星对常见敏感菌的MIC参数考虑,可以认为,口服10mg/kg剂量可以满足临床养殖中抗敏感细菌感染的要求。

The pharmacokinetics of enrofloxacin were investigated in geese. Thirty-six geese were ran- domly divided into 2 groups （Group A and B）. The birds in Group A and B were given an intravenous and oral administration of 10 mg/kg of bodyweight, respectively. Data analysis was performed with DAS 2.0. Results showed that there were significant differences in some pharmacokinetics parameters. AUC and to tal body clearance in Group A were 1.3 times and 0.6 times of those in Group B, respectively. After ad- ministration, enrofloxacin was eliminated quickly in Group A, however, the value of mean residence time was seven-tenth of that in Group B. Considering the MIC90 of enrofloxacin against sensitive bacteria, a dose of 10 mg/kg could meet the request of anti-infection in clinical practice.