阿德呋啉血药浓度的测定及其在鸡体内药代动力学研究

Determination of the plasma adprin concentrations and studies on its pharmacokinetics in chickens after oral administration

采用高效液相紫外检测法,测定了健康鸡灌服80 mg·kg-1阿德呋啉后血浆中药物浓度,药物浓度-时间数据用3P97药代动力学程序软件处理。血药浓度-时间数据符合一级吸收二室开放模型,其主要药代动力学参数分别为:血浆消除半衰期(T1/2β)(2.414±0.252)h,达峰时间(Tpeak)(1.429±0.053)h,达峰浓度(C max)(499.941±21.295)ng·mL-1,药时曲线下面积(AUC)(2 624.528±124.690)ng·h·mL-1。阿德呋啉在试验鸡体内的相对生物利用度为61.94%。结果表明:阿德呋啉在健康鸡体内的药代动力学特征表现为吸收迅速,相对生物利用度较高,消除缓慢,组织穿透性差,不易在机体中残留。

This paper deals with the plasma adprin concentrations in chicken fed with 80 mg-kg-＇ adprin by using high performance liquid chromatography. Plasma adprin pharmacokinetic variables are calculated by using a two-compartment model with 1 st order absorption in chicken with 31097 pharmacokinetics program. The main pharmaeokinetics parameters are as follows ：elimination half-lives of plasma adprin is （2. 414±0. 252）h; peaking time after dosing the drug to chickens is （1. 429 ±0. 053）h;the maximal plasma concentration is （499. 941±21. 295 ） ng. mL-1 ; the area under the curve of drug is （ 2 624. 528 ± 124. 690） ng. h. mL-1 respectively in chicken. The relative bioavailability of adprin in chicken is 61.94%. The results suggested that the pharmacokinetic stigmata of adprin in healthy chicken are quick absorption, higher relative bioavailability, slow-elimination ,bad-penetration and lower-residue in tissue.