神经营养因子对视网膜缺血再灌注损伤的影响

Effect of neurotrophic factors on retinal ischemia-reperfusion injury

视网膜缺血再灌注损伤是由于自由基、炎性细胞因子等细胞微环境的改变引起的病理过程,能造成视网膜及神经组织严重损伤。微环境包括对细胞产生影响的周围结构和成分,如附近的神经细胞、基质细胞和结合在胞外基质上的各种生长因子和细胞因子等。这些因子有的具有保护视网膜作用,如神经生长因子、睫状神经营养因子、脑源性神经营养因子、碱性成纤维细胞生长因子等;有的具有损伤作用,如血管内皮生长因子等。本文结合文献以这些因子在视网膜缺血再灌注损伤中的作用作一综述。

Retinal ischemia-reperfusion injury is a pathological process, caused by cell microenvironment change such as free radicals, inflammatory cytokines and can bring about serious damage for the retina and nerve tissue. Microenvironment is maked up of the structure and composition around cells, for instance, nerve cel｜s, stromal cells and various growth factors and cytokines combined with the extracellular matrix. Some of these factors can protect the retina,for example, nerve growth factor, ciliary neurotrophic factor, brain derived neurotrophic factor, basic fibroblast growth factor and so on. However, vascular endothelial growth factor has damage effect. This article assesses effects of these factors in retinal ischemia-reperfusion injury.