MRI分子探针在阿尔茨海默病诊断的应用

Application of MRI molecular probes in the diagnosis of Alzheimer's disease

淀粉样斑块是阿尔茨海默病(Alzheimer's disease,AD)早期最具特征性的病理改变,因此它可以作为早期诊断AD的重要指标,但传统的磁共振成像技术并不能很好探测AD的早期病理学改变。Aβ是淀粉样斑块的核心成分,它与某些特定化合物如硫磺素衍生物和刚果红衍生物等具有较强的亲和力,也能与一些多肽以及Aβ抗体结合,研制成基于相关化合物的分子探针,并把此类探针与磁共振成像技术相结合探测AD患者脑内的淀粉样斑块。本文就目前用于AD诊断的MRI分子探针的研究进展进行综述。

Amyloid plaque is one of the earliest distinctive pathological changes in Alzhcimer＇s disease（AD） patients, thus detection of the plaques is the most important early diagnostic indicator of AD. It is important to diagnose AD in early stage or to differentiate AD from other dementia subtypes, however conventional magnetic resonance imaging（MRI） could not satisfy this need. Amyloid β peptides（A β） is the core element of the amyloid plaques, has a strong affinity for special chemical compound such as the derivatives of sulfur element, the derivatives of Congo red, some peptides and the antibody of Aβ, so the molecular probes based on related compounds were developed and combined with MR1 to diagnose AD at the early stage. This review outlines the research progress of MRI molecular probes in AD diagnosis.