云母对NSAIDs相关性胃肠病的防治作用

Role of Mica for Prevention and Treatment of NSAIDs-related Gastrointestinal Disease

随着非甾体消炎药(NSAIDs)被广泛应用于骨关节炎、类风湿性关节炎以及心脑血管疾病的治疗和预防,其胃肠道不良反应逐渐引发关注。中药云母具有天然层状结构和特殊的物理性质,可吸附于黏膜表面,发挥黏膜保护作用。研究发现云母对NSAIDs相关性胃肠病具有预防和治疗作用,其起效机制可能包括维持胃肠道屏障功能、促进胃肠黏膜损伤修复、抑制和吸附促炎细胞因子以及抗脂质过氧化等。本文对相关内容作一综述。

As non-steroidal anti-inflammatory drugs （NSAIDs） are widely prescribed for the treatment and prevention of osteoarthritis, rheumatoid arthritis and cardiovascular and cerebrovascular diseases, its adverse effect on gastrointestinal tract is deeply concerned. Mica is a traditional Chinese drug that possesses natural lamellar structure and some specific physical properties. It may adhere to the mucosa and exert mucosal protective effect. Many studies revealed that mica could be used for prevention and treatment of NSAIDs-related gastrointestinal disease, and the maintenance of gastrointestinal barrier function, repairing of mucosal injury, inhibition and adsorption of proinflammatory cytokines and anti-lipid peroxidation might be involved in the mechanisms of mica for controlling NSAIDs-related gastrointestinal disease. The relevant issues were reviewed in this article.