摘要
目的研究肺表面活性蛋白A、D(sP—A、sP—D)和KL-6在肺炎支原体肺炎(MPP)血清和支气管肺泡灌洗液(BALF)中变化及意义。方法采用自身对照的方法,根据肺cT影像结果对32例单侧肺实变MPP患儿血清、患侧和健侧BALF中sP—A、sP—D与KL-6进行检测和统计分析。结果32例MPP患儿患侧BALF中sP—A、sP—D和KL-6含量分别为[mg/L,M(加R)]:243(90~468),187(43—333),148(47—426);健侧分别为:104(37~257),56(25~131),35(12~147);血清中分别为:35(25~69),33(9—149)和24(15~62)。血清中KL-6与患侧和健侧BALF中KL-6的相关系数分别是-0.534和-0.378(P〈0.05)。结论CAP患儿血清中SP—A、SP—D和KL一6水平变化与肺组织感染具相关性,血清中KL-6可能比SP-A、SP—D更为敏感。
Objective To study the alterations and relationship of surfactant protein (SP)-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluids ( BALF ) in children with Mycoplasma pneumoniae pneumonia (MPP). Method Self-control method was used for the study on SP-A, SP-D and KL-6 in serum,infected and non-infected BALFs in 32 MMP children with only one side of MPP. Result The contents of SP-A,SP-D and KL-6 in infected BALF were E rag/L; M (IQR) 1 : 243 ( 90 - 468 ), 187 (43 - 333) ,148(47-426) ;104(37-257) ,56(25-131) ,35(12- 147) in non-infected BALF; 35(25 -69), 33 (9 - 149 )and 24( 15 -62)in serum. The correlation coefficient of KL-6 between serum and infected BALF were - 0. 534 and - O. 378 ( P 〈 0. 05 ) . Conclusion There were significant correlation between the alterations of SP-A ,SP-D and KL-6 in serum and lung infection in children with CAP. KL-6 in serum may be more sensitive than SP-A and SP-D.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2013年第10期779-782,共4页
Chinese Journal of Pediatrics
基金
辽宁省自然科学基金(201102265)
辽宁省科技攻关课题(2012225021)
沈阳市科学技术项目(F11-264-1-06)