垂体后叶素、米索前列醇和缩宫素联合治疗产后出血的临床观察

Clinical observation of vasopressin, misoprostol combined with oxytocin in treatment of postpartum hemorrhage

目的探讨垂体后叶素、米索前列醇和缩宫素联合用药治疗产后出血的临床效果。方法选取我院2011年1月-2013年3月住院分娩并应用以上三种药物联合治疗及预防产后出血的孕产妇作为研究对象，用药例数为849例，计算期间所有分娩患者的出血率，并与2008年1月～2010年12月分娩患者出血率比较。结果2011年1月～2013年3月患者用药后的出血率和2008年1月～2010年12月出血率比较降低了45．9％，且2011年1月。2013年3个月内无一例因宫缩乏力导致的产后出血需要子宫切除。结论应用垂体后叶素、米索前列醇和缩宫素联合预防和治疗宫缩乏力导致的产后出血，降低了产后出血率，避免了产后出血对产妇健康所带来的危害，降低了孕产妇死亡率。

Objective To investigate the clinical effect of vasopressin, misoprostol combined with oxytocin in treatment of postpartum hemorrhage. Methods Eight hundred and forty nine delivery pregnant women used vasopressin,misoprostol combined with oxytocin to treat and prevent postpartum hemorrhage in our hospital during January 2011 to March 2013 were selected as the object of study,the hemorrhage rate of all delivery patients during the period were calculated,and were compared with the hemorrhage rate of delivery patients during January 2008 to December 2010. Results Compared with during January 2008 to December 2010,the hemorrhage rate of delivery patients after using drugs during January. 2011 to March 2013 reduced 45.9%,and no a case of postpartum hemorrhage caused by uterine inertia underwent hysterectomy during January 2011 to March 2013. Conclusion Using vasopressin,misoprostol combined with oxytocin in treatmentand prevention of postpartum hemorrhage caused by uterine inertia reduce the rate of postpartum hemorrhage,avoid the harm for maternal health caused by postpartum hemorrhage,and reduce maternal mortality.