左氧氟沙星分散片联合抗结核化疗方案治疗初治涂阳肺结核的疗效观察

Levofloxacin dispersible tablets plus antituberculosis chemotherapy on treating initial smear-positive pulmonary tuberculosis

目的探讨初治涂阳肺结核采用左氧氟沙星注射液联合抗结核化疗方案治疗的临床实践效果。方法收取2012年6月～2013年6月在我院治疗的初治涂阳肺结核100例，随机分为实验组和对照组，两组各50例。实验组采用2HRZE／4HR治疗方案加入左氧氟沙星分散片，对照组采用2HRZE／4HR治疗方案，整个疗程为6个月，统计用药2、4、6个月以后检测患者的痰菌的阴转率、病灶吸收率，并密切观察患者症状的改善情况、ADR情况，分析两种治疗方法的临床治疗效果。结果痰菌的阴转率实验组优于对照组，病灶吸收率实验组优于对照组，两组间差异具有统计学意义（P〈0．05）。结论复治涂阳肺结核采用左氧氟沙星联合抗结核化疗方案临床效果显著，具有推广应用价值。

Objective To study the clinical practice effect of initial smear-positive pulmonary tuberculosis with levofloxacin injection combined withchemotherapy in the treatment of tuberculosis. Methods 100 cases of patients with initial smear-positive pulmonary tuberculosis were selected from June 2012 to June 2013 in our hospital and were randomly divided into experimental group and control group, two groups of 50 cases. The experimental group was treated with 2HRZE/4HR scheme of adding levofloxacin dispersible tablets, the control group was treated with 2HRZE/4HR scheme, the whole course of treatment for 6 months, then gathered the sputum negative conversion rate of detection of the patient, the focus absorption rate, the improvement of the patients＇ symptoms, ADR and closely observe the patientsymptom after 2, 4, 6 monthes, and analyzed the clinical curative effect of the two treatment methods. Results The sputum negative conversion rate of the experimental group was significantly better than the control group, the focus absorption rate of experimental group was better than the control group, the difference between the two groups was statistically significant （P 〈 0.05）. Conclusion The treatment of smear-positive pulmonary tuberculosis withlevofloxacin combined with antituberculosis chemotherapy clinicaleffect is remarkable, and has popularization and application value.