兴安盟地区同型半胱氨酸水平在脑卒中患者中的意义

Significance of homocysteine level on patients with cerebral apoplexy in Xing'an league region

目的探讨血清同型半胱氨酸（Hcy）水平与缺血性脑卒中的相关性，为临床诊断和治疗提供有效的依据。方法运用流行病学病例对照及确诊病例为研究方案，采用循环酶法对2011年11月～2013年6月为人住兴安盟人民医院神经内科脑卒中患者151例（观察组）及同期153例健康体检者（对照组）进行Hcy的检测分析，比较两组间Hcy水平差异，分析Hcy水平与脑卒中发病的关系。结果血清Hcy水平，观察组为（24．2±17．7）μmol／L，明显多于正常对照组的（13．4±3．44）μmol／L，数据比较有统计学意义（P〈0．01），以Hcy〉20μmol／L为高Hcy标准，观察组的发病率为33．1％，对照组发病率为0，两组数据比较有统计学意义（P〈0．01）。结论血清高Hcy的水平与脑卒中的发生具有相关性，通过检测Hcy的含量可对临床的诊断治疗起指导作用，因此积极推广Hcy的测定可以有效减少疾病的发生，对预防脑卒中有积极的临床意义。

Objective To investigate the relationship between serum homocysteine（Hcy） level and cerebral arterial thrombosis in order to provide an effective basis for clinical diagnosis and treatment. Methods The Hcy level of 151 inpatients with cerebral apoplexy（the observation group） in neurology department of the people＇s hospital of Xing＇an league during November 2011 to June 2013 and 153 healthy examined people during the same period（the control group） were detected and analyzed by applying epidemiological case-control and confirmed cases study program and circulatory enzyme method. The Hcy level of the two groups was compared, and the relationship between Hcy level and incidence of cerebral apoplexy was analyzed. Results The serum Hcy level in the observation group（24.2 ± 17.7） μ mol/L was significantly more than that in the control group（13.4 ± 3.44）μ mol/L, and the difference was statistically significant（P 〈 0.01）. The serum Hcy level more than 20μmol/1 was as the standard of high Hcy,the incidence of cerebral apoplexy in the observation group was 33.1%, the incidence of cerebral apoplexy in the control group was 0, and the difference was statistically significant（P 〈 0.01）. Conclusion The high serum Hcy level and incidence of cerebral apoplexy has correlation, the determination of Hey level has guidance on clinical diagnosis and treatment, thus actively promoting the Hcy determination can effectively reduce the incidence of disease,and has positive clinical Significance on the prevention of cerebral apoplexy.