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低度慢性炎症与2型糖尿病 被引量：39

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摘要 糖尿病是严重危害人类健康的全身性代谢疾病，但病因迄今未阐明。1999年Schmidt等首次提出炎症介质可预测2型糖尿病的发生，后续的基础和临床研究进一步支持了糖尿病的炎症病因学理论，形成2型糖尿病发病的炎症学说。此学说认为糖尿病是由炎症因子介导的慢性低度炎症性疾病，系一种慢性、亚临床性、非特异性免疫介导的炎症，包括非特异性的炎症细胞、炎症细胞分泌的炎症因子和肝脏产生的急性反应物质，这种慢性炎症不同于感染、损伤等应激因素作用下的炎症反应，
作者 杨立勇
机构地区 福建医科大学附属第一医院内分泌科
出处 《中华糖尿病杂志》 CAS CSCD 2013年第9期527-530,共4页 CHINESE JOURNAL OF DIABETES MELLITUS
关键词 2型糖尿病 慢性炎症 全身性代谢疾病 炎症学说 炎症因子 免疫介导 非特异性 炎症性疾病
分类号 R587.2 [医药卫生—内分泌]
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参考文献27

  • 1Schmidt MI,Duncan BB,Sharrett AR,et al.Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Riskin Communities study):a cohort study.Lancet,1999,353:1649-1652.
  • 2Pradhan AD,Manson JE,Rifai N,et al.C-reactive protein,interleukin 6,and risk of developing type 2 diabetes mellitus.JAMA,2001,286:327-334.
  • 3Freeman DJ,Nor'ie J,Caslake MJ,et al.C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study.Diabetes,2002,51:1596-1600.
  • 4Festa A,D'Agostino R Jr,Tracy RP,et al.Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes:the insulin resistance atherosclerosis study.Diabetes,2002,51:1131-1137.
  • 5Brooks-Worrell BM,Reichow JL,Goel A,et al.Identification of autoantibody-negative autoimmune type 2 diabetic patients.Diabetes Care,2011,34:168-173.
  • 6Tabák AG,Kivimaki M,Brunner EJ,et al.Changes in Creactive protein levels before type 2 diabetes and cardiovascular death:theWhitehall Ⅱ study.Eur J Endocrinol,2010,163:89-95.
  • 7Schroder K,Zhou R,Tschopp J.The NLRP3 inflammasome:a sensor for metabolic danger?.Science,2010,327:296-300.
  • 8Carstensen M,Herder C,Kivimaki M,et al.Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years beforediagnosis of type 2 diabetes:Whitehall Ⅱ prospective cohort study.Diabetes,2010,59:1222-1227.
  • 9Luotola K,Pietil(a) A,Zeller T,et al.Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levelsand the development of type 2 diabetes.J Intern Med,2011,269:322-332.
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二级参考文献7

  • 1Asfari M, Janjic D, Meda P, et al. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology,1992,130 : 167-178.
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共引文献9

同被引文献360

引证文献39

二级引证文献226

中华糖尿病杂志
2013年 第9期

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