空腹和餐后手指末梢血糖与静脉血糖浓度差异的比较分析

Analysis and comparison of glucose concentration between capillary and venous glucose in fasting or postprandial state

目的分析比较空腹和餐后2h手指末梢全血、血浆与静脉全血、血浆4种不同血样葡萄糖浓度之间的差异。方法2010年8月至12月共140例1型或2型糖尿病患者纳入试验。其中男56例、女84例，年龄（54±10）岁。空腹血糖82例．餐后2h血糖58例，每例患者采集手指末梢全血、血浆以及静脉全血、血浆4种血样。用OneTouchVerio血糖监测系统和YSI2300葡萄糖测定仪，分别检测末梢血血糖（CBG）、静脉血糖（VBG）与末梢血浆血糖（CPG）、静脉血浆血糖（VPG）。并对Verio血糖监测系统的精准性进行评估。血糖数值差异分析采用配对t检验法。结果Verio血糖监测系统的精准性符合IS015197（2003）标准要求。空腹状态下血糖仪检测的CBG与VBG分别为（6．7±2．4）、（6．7±2．3）mmol／L，相对误差为0．40％（t=0．62，P〉0．05），YSI检测的CPG与VPG分别为（6．4±2．5）、（6．4±2．4）mmol／L，相对误差为0．25（t=0．39，P〉0．05），CBG略高于VPG5．89％（P〈0．05）；餐后2hCBG明显高于VBG，分别为（8．5±3．6）、（7．9±3．6）mmol／L，相对误差为7．58％（t=9．55，P〈0．05）；CPG亦明显高于VPG水平，分别为（8．1±3．8）、（7．6±3．8）mmol／L，相对误差为6．08％（t=10．9，P〈0．05），CBG高于VPG11．6％（P〈0．05）。结论OneTouchVerio血糖监测系统适合临床对患者进行日常血糖检测，其检测的空腹CBG与VPG值较为接近，餐后CBG高于VPG值。

Objective To analyze and compare the difference between the finger capillary blood glucose （ CBG）, capillary plasma glucose （ CPG）, venous blood glucose （VBG） and venous plasma glucose （VPG） in fasting or 2-hour postprandial state. Methods One hundred and forty patients with type 1 or type 2 Diabetes Mellitus patients （56 males and 84 females with mean age （54 -± 10 ）years and 82 patients with fasting and 58 with 2-hour postprandial glucose ） were included in this study. Four different blood samples were measured for each patient simultaneously. CBG and VBG was measured using One Touch Verio blood glucose monitoring systetru CPG and VPG was measured using YSI 2300 glucose analyzer as a reference method. A clinical evaluation of accuracy of One Touch Verio glucose monitoring system was conducted. Results The accuracy of Verio blood glucose monitoring system met the requirements of ISO 15197 （2003） standard. In fasting state, CBG and VBG which detected by blood glucose monitoring system was （ 6.7 ± 2.4） mmol/L and （6. 7 ±2. 3） retool/L, respectively. The relative error was 0. 40% （t =0. 62 ,P 〉0. 05）. CPG and VPG which detected by YSI was （ 6. 4 ± 2. 5 ） mmol/L and （ 6. 4 ± 2.4 ） mmol/L, respectively. The relative error was 0.25% （t =0.39 ,P 〉0.05）. CBG were slightly higher than VPG. The relative error was 5.89% （P 〈 O. 05 ）. In 2-hour postprandial state, CBG and VBG were （8.5 ± 3.6） mmol/L and （7.9 ± 3.6） mmoL/L, respectively. The relative error was 7.58% （t = 9. 55,P 〈 0. 05）. CPG and VPG was （8.1 ±3.8） mmol/L and （7.6 ±3.8） mmol/L, respectively. The relative error was 6.08% （t = 10.9 ,P 〈0. 05 ）. CBG was obviously higher than VPG. The relative error was 11.6%, P 〈 0. 01. Conclusions One Touch Verio glucose monitoring system is suitable for clinical monitoring of blood glucose and also for SMBG, the fasting CBG values are close to those of the VPG. The postprandial CBG values are higher than those of the VPG.