^(125)I粒子CT靶向治疗实体肿瘤

Interventional Treatment for Solid Tumors by CT-guided ^(125)I Seed

目的探讨实体肿瘤CT靶向125I粒子瘤内植入、近距离放射治疗的方法与疗效。方法经明确诊断不同部位恶性肿瘤患者60例,在CT引导下将125I粒子永久性植入瘤体内近距离内放射性治疗。根据病人的临床表现及影像学检查判断病人是处于完全缓解,部分缓解,稳定-无变化,同时比较术前和术后28d患者血液学指标的差异。结果 60例顺利完成125I粒子植入手术,无一例发生严重并发症。60例81个病灶中,6 8个病灶布源满意,满意率8 4.0%,随访3~36月,25例完全缓解;30例46个病灶部分缓解;稳定5例10个病灶。总有效率87.7%。统计学分析,P<0.05,差异有显著性意义。比较本组患者术前和术后第28天外周血红细胞数、血红蛋白量、血小板数、白细胞计数、中性粒细胞数、淋巴细胞数与术前相比差别无统计意义(P>0.05)。结论 CT靶向进行125 I粒子植入技术治疗实体肿瘤,可以增加局部肿瘤放疗剂量,能有效控制肿瘤生长,延长患者复发时间及生存时间,提高患者生存质量。此技术适应证广,安全有效,为恶性实体肿瘤的综合治疗增添了新的手段。

Objective To investigate the methods and efficacy of CT-guided 125I Seeds implantationan brachytherapy for solid turners. Methods 60 cases of patients with clear diag- nosis of malignant cancer in different parts of the body, underwent CT-guided 125Il Seeds permanently implanting in vivo as brachytherapy. To get the Judgment based on the patients＇ clinical and imaging manifestations to evaluate the condition of patients： in complete remission, in partial remission or no change, while comparing differences of preoperative and postopera- tive 28th in blood parameters. Results 60 cases were implanted successfully with no severe complication. 81 lesions of 60 cases. 68 lesions satisfied,satisfaction rate of 84.0%（68/81）： During a follow-up period of 3-36 months. 25 cases were completely in remission, 46 lesions of 30 cases were partly in remission, 5 cases of 10 lesion were no change, the overall effective rate was 87.7%. Statistics analysis： P〈0.05, the differences were significantly meaningful. Compare the patients＇peripheral blood cell count,hemoglobin,plaelet count, white blood cell count, neutrophil count, lymphocyte count of postoperative 28th to preoperative, the difference was not statistically significicant（P 〉 0.05）. Conclusion The treatment of CT-guided 125I Seed Implantation for malignant tumor can increase the local radiotherapy dose.thus controlling the growth of tumor effectively, prolonging the time of recurrence and survival time.Improv- ing the quality of life. This treatment with wide indication is sate and effective, it added a new means for the treatment of malignant solid tumors.