电针对实验性血管性痴呆大鼠学习和记忆功能的影响

Influence of Electroacupuncture on Learning and Memory in Vascular Dementia Rats

本文探讨了针刺对实验性血管性痴呆 (VD)大鼠学习记忆能力的影响。将实验大鼠随机分为正常组、假手术组、模型组、电针组和尼莫通组 ,采用改良的四血管阻断法建立血管性痴呆大鼠模型 ,进行Morris水迷宫测试。结果 :模型组、西药组、电针组大鼠造模后学习记忆能力明显下降 ,但经过电针和尼莫通治疗 ,电针组与尼莫通组水迷宫成绩显著改善 (与模型组比较 ,P <0 0 1 ) ,电针组效果优于尼莫通组。认为电针可能是通过对大鼠中枢胆碱能系统的改变来实现其治疗效果的。

To investigate the influence of electroacupuncture (EA) on learning and memory in vascular dementia (VD) rats.Methods:70 SD rats were randomly divided into 5 groups: normal control group (n=10),false operation group (n=10), VD model group (n=15), VD model + EA group (n=17) and VD model + medication group (n=18).VD model was established by using a modified Pulsinelli's 4 vessel occlusion method. And then all the rats accepted Morris water maze test and accorded with our experimental demands. In rats of EA group, “Baihui' (DU 20)and “Dachangshu' (GB 14) were punctured and stimulated with an EA Therapeutic Apparatus. SD rats in medication group were administered with nimotop. Results:After generation of VD, the learning and memory capability of rats in VD model, VD model + EA and VD model + medication groups declined apparently in comparison with that of control group and false operation group. However, comparison between VD model group and EA+VD model group or VD + medication group showed that both EA and medication could obviously improve the learning and memory capability (P<0.01); and the effect of EA was superior to that of medication. Conclusion: EA can improve the learning and memory ability in VD rats.