羟甲烟胺片联合铝碳酸镁、莫沙必利治疗胆汁反流性胃炎243例疗效观察

Observation on the Therapeutic Effect on the Treatment of 243 Cases of Bile Reflux Gastritis through Using Hydroxymethylnicotinamide Tablets with Hydrotalcite and Mosapride

目的:探讨羟甲烟胺片联合铝碳酸镁、莫沙必利治疗胆汁反流性胃炎的疗效。方法:243例胆汁反流性胃炎患者随机分成三组,莫沙必利组:莫沙必利5 mg,餐前服,3次/d;莫沙必利+铝碳酸镁组:莫沙必利5 mg,餐前服,3次/d,铝碳酸镁1.0 g,饭后1 h嚼服,3次/d;莫沙必利+铝碳酸镁+羟甲烟胺片组:莫沙必利5 mg,餐前服,3次/d,铝碳酸镁1.0 g,饭后1 h嚼服,3次/d,加羟甲烟胺片0.5 g,饭后0.5 h服,3次/d。疗程均为6周,采用临床症状总疗效和胃镜结果进行量化评分,计算有效率。结果:莫沙必利+铝碳酸镁+羟甲烟胺片组治疗胆汁反流性胃炎有效率高于莫沙必利+铝碳酸镁组和莫沙必利组,差异均有统计学意义(均P<0.05)。结论:莫沙必利+铝碳酸镁+羟甲烟胺片治疗胆汁反流性胃炎起到了协调增强作用,效果明显,多途径阻断胆汁反流性胃炎的发病机制,治愈率高,建议胆汁反流性胃炎使用羟甲烟胺片联合铝碳酸镁、莫沙必利治疗方案治疗。

Objective： To research and discuss the therapeutic effect on the treatment of bile reflux gastritis through using hydroxymethylnicotinamide tablets with hydrotalcite and mosapride.Method： 243 cases of bile reflux gastritis were randomly divided into 3 groups.Group One was mosapride group, in which patients took 5 mg tid mosapride before they had meals.Group Two was mosapride and hydrotalcite group, in which patients took 5 mg tid mosapride before meals, and chewed 1.0 tid hydrutalcite one hour after meals.Group Three was mosapride and hydrotalcite and hydroxymethylnicutinmide tablets group, in which patients took 5 mg tid mosapride before meals, chewed 1.0 g rid hydrotalcite one hour after meals, and took 0.5 g rid hydroxymethylnicotinamide tablets one half hour after meals.The period of the treatment lasted six weeks.Quantitative evaluation on the effective rates of the three groups took use of the total herapeutic effect of the clinical symptoms and of the results from gastroscopy.Result： There were significantly differences in comparing the three groups（P〈0.05）.The effective rate of Group Three was higher than Group One and Group Two.Conclusion： It plays a coordinative and enhancive role in the treatment of bile reflux gastritis through using hydmxymethylnicotinamide tablets with hydmtalcite and mosapride.It turns out good therapeutic effect and high curative rate with multi-path block to pothogenesy system.Therefore, it is recommended to employ the treatment scheme through using the hydroxymethylnicotinamide tablets with hydrotalcite and mosapride to treat bile reflux gastritis.