摘要
目的探讨黄芪对创伤性脑损伤后脑组织线粒体超氧化物歧化酶（ ＳＯＤ）和丙二醛（ ＭＡＤ）水平的影响。方法建立自由落体脑挫裂伤模型，伤后立即腹腔注射黄芪注射液，采用生化检测的方法分别测定治疗后４小时、２４小时和４８小时及各自的对照组大鼠脑组织线粒体ＳＯＤ和ＭＤＡ水平。结果黄芪治疗后２４小时和４８小时脑组织线粒体ＳＯ Ｄ水平均高于各自时间点对照组（Ｐ＜０．０１），而ＭＤＡ水平则明显低于各自对照组（Ｐ＜０．０１）。结论黄芪治疗可以通过影响线粒体功能而减轻创伤性脑损伤后的继发性脑损害，从而改善预后。
Objective To investigate the therapeutic effects of Huangqi on the activity of SOD and the level of MDA in brain mitochondria after brain trauma in rats. Methods The HUangqi was intraperitoneally injected immediately following brain traumai resulted from free-falling. The mitochondria of brain cells were isolated at 4h,24h and 48h after trau- ma respectively, while the activity of SOD and the content of MDA were measured. Results Activity of SOD .was elevated and the level of MDA was reduced markedly in rats treated with Huangqi(P < 0.01 ). Conclusion Treatment with Huan- gqi can improve the activity of SOD, reduce the level of MDA in brain mitochondria after brain trauma in rats.
出处
《创伤外科杂志》
2000年第4期204-206,共3页
Journal of Traumatic Surgery
基金
上海第二医科大学科研基金资助项目
