肿瘤多药耐药模型的建立与评价方法

Establishment of tumor multidrug resistance model and its evaluation methods

开发多药耐药肿瘤的细胞模型和动物模型对于其相关基础研究和药物评价意义重大。综述了肿瘤多药耐药模型的建模方法,分别对细胞模型和荷瘤动物模型的建立类型、各自特点、评价手段及研究意义等进行了分析和总结。为建立优势肿瘤多药耐药模型、优化现有抗肿瘤药物评价方法提供参考,有助于阐明多药耐药相关机制,并为临床用药提供指导。

This study intends to review the methods of building tumor multidrug resistance（MDR） models and animal model.The establishment methods,characteristics,evaluation tools,and the study significance of the models including MDR cells and MDR animals were analyzed and summarized.It could provide a reference to establish an advanced MDR model,and to optimize the evaluation model of antitumor drugs.It could also be helpful to clarify the mechanisms of MDR and may provide the guidance for the clinical usage of antitumor drugs.