摘要
目的比较腹腔镜与开腹直肠癌根治术对血浆血管内皮生长因子（VEGF）水平的影响。方法前瞻性纳入汕头市中心医院在2011年1月至2012年12月间的100例直肠癌根治术患者，根据患者个人意愿分为腹腔镜手术组（LR组，63例）和开腹手术组（OR组，37例）。LR组直肠前切除（Dixon）术44例，腹会阴联合直肠癌切除（Miles）术19例；OR组Dixon术26例，Miles术11例。采用双抗体夹心酶联免疫吸附试验检测两组术前1d和术后第1、3、7天血浆VEGF水平。结果LR组术后患者血浆VEGF水平均缓慢上升，至术后第7天时VEGF水平较术前明显升高（P〈O．01）：OR组术后第1天VEGF水平即较术前明显升高（P〈O．05）。LR组与OR组在术前1d和术后第1天VEGF水平的差异均无统计学意义（均P〉O．05），但术后第3天和术后第7天OR组VEGF水平显著高于LR组（均P〈O．05）。结论与开腹手术相比，腹腔镜直肠癌根治术对患者血浆VEGF水平的短期影响较小。
Objective To investigate the effect of laparoseopic and open proctectomy on plasma levels of vascular endothelial growth factor （VEGF）. Methods From January 2011 to December 2012, 100 rectal cancer patients in Shantou Central Hospital were enrolled in the study. Patients were divided into laparoscopic （LR） group and open （OR） group based on the decision of the patients. There were 63 patients in the LR group （44 cases undergoing low anterior resection and 19 abdominoperineal resection） and 37 patients in the OR group（26 cases undergoing low anterior resection and 11 abdominoperineal resection）. Double antibody sandwich enzyme-linked immunohistochemistry was used to detect the level of VEGF on 1-day before and 1-day, 3-day, 7-day after operation. Results In the LR group, the postoperative levels of VEGF increased slowly, and the level of VEGF was significantly higher than that before operation until the 7-day after operation （P〈0.05） regardless of the procedure. In the OR group, all the postoperative levels of VEGF were significantly increased （P〈 0.05）. There was no significant difference of the VEGF level on I-day before and 1-day after operation between the two groups（all /〉〉0.05）. The VEGF level in the OR group was significantly higher than that in the LR group on the day 3 and day 7 after operation（P〈O.05）. Conclusion Compared with open approach, laparoscopic procteetomy has smaller short-term impact on the plasma level of VEGF in rectal cancer patients.
出处
《中华胃肠外科杂志》
CAS
CSCD
2013年第10期989-992,共4页
Chinese Journal of Gastrointestinal Surgery
基金
广东省汕头市科技计划项目（2010-178）
