聚乙二醇/聚己内酯嵌段共聚物温敏水凝胶及其在局部药物递送中的应用

Thermosensitive Hydrogels Based on PEG/PCL Block Polymer and Their Applications in Local Drug Delivery

近年来,温敏水凝胶被广泛用于药物递送、组织工程等生物医用领域.其中,由聚乙二醇与脂肪族可降解聚酯合成的两亲性聚合物的自组装胶束形成的温敏水凝胶是一种重要的温敏凝胶材料.本文针对聚乙二醇(PEG)与聚己内酯(PCL)形成的两亲性嵌段聚合物温敏水凝胶体系,综述了聚合物分子质量、嵌段序列结构,亲疏水段分子质量与比例、疏水段化学结构等因素对温敏行为的影响,以及该温敏水凝胶在局部药物递送方面的研究进展.

For the past few years, thermosensitive hydrogels have been widely used in biomedical field including drug delivery system, tissue engineering and so on. Thermosensitive hydrogels formed with micelles assembled by amphiphilic block polymer based on polyethyleneglycol （PEG） and biodegradable polyesters play an important role among these hydrogels. In the present review, we summarize the effects of molecular weight, sequence of segments, ratio between hydrophilic and hydrophobic block and structure of hydrophobic block on the thermosensitive behavior of aqueous solution of amphiphilic block polymer synthesized by PEG and ε-polycaprolactone. The progresses of the thermosensitive hydrogel in the local drug delivery are also explored.