基于聚合物的环境敏感型纳米抗肿瘤药物传输系统的研究

Environment-responsive Polymeric Nanoparticles as Drug Delivery Systems for Cancer Therapy

环境敏感型聚合物纳米抗肿瘤药物传递系统能够响应外界环境的微小刺激,引起自身结构的变化,释放出药物,在肿瘤治疗方面具长效低毒、可控及高载药量等优势,已被广泛应用于生物医学领域.本文介绍了聚合物环境响应型纳米药物传输系统的发展近况,并从pH值敏感型、温度敏感型、氧化还原敏感型、酶敏感型以及其他敏感型给药系统角度,阐述了环境敏感型药物传输系统在抗肿瘤领域的研究现状及未来展望.

Environment-responsive polymeric nanoparticles as antitumor drug delivery systems could response to tiny environmental stimulus, change their structure and release the antitumor drug. They have been widely applied in biomedical area due to their considerable advantages of prolonging survival time with lower toxicity, controllability and high drug loading in cancer therapy. Here, we present an overview of the recent work on environment-responsive polymeric nanoparticles as drug delivery systems for cancer therapy, including pH sensitive, temperature sensitive, redox sensitive and enzyme sensitive, based on the domestic and international research progress. In addition, recent advances and future directions in the development of environment- responsive polymeric nanoparticles as antitumor drug delivery systems are also included.