磁性纳米材料在组织工程研究中的应用

Application of Magnetic Nanoparticles in Tissue Engineering

磁性纳米材料因其独特的理化性质在组织工程研究中被广泛地应用.本文主要从磁性纳米材料的表面化学活性、磁学性质以及生物应用磁性纳米材料的主要合成方法等几方面,综述了近年来利用磁性纳米材料设计组织工程支架材料的相关研究进展,包括纳米条件下的生长因子及相关基因的包裹和释放、机械力学刺激、干细胞追踪以及细胞图案化.

On account of its unique physicochemical properties, magnetic nanoparticles attracts many attentions in its applications of tissue engineering. Here, we briefly described two major characteristics of magnetic nanoparticles, surface chemical activity and the magnetic properties. The main synthesis methods of magnetic nanoparticles in biomedicine was included. Based on the two major characteristics of magnetic nanoparticles, we mainly reviewed methods of the designing biomaterials in tissue engineering and the assembling growth factors or genes released vector. We also summarized the research progress of mechanical stimulation, stem cell labeling, tracking and cell patterning on the magnetic nanoparticles construction in this paper.