原发性浆细胞性口炎临床表征及分析

Analysis of clinical symptom of primary plasma cell stomatitis

目的：分析原发性浆细胞性口炎的临床特点，为该病的诊治提供有价值的参考。方法：使用电了文献数据库、中英文纸质文献数据库、网络引擎、临床收集4种方法收集原发性浆细胞性口炎的病例报道，提取有效的与临床紧密相关的资料进行统计分析。结果：43篇合格文献纳入本研究，加上2例临床患者，共88例患者病例资料。分析结果示：原发性浆细胞性口炎在北美洲病例数最多（38例），男性：女性=7：15，半均年龄43．39±18．86岁，发病多存21～30岁和5l～60岁之间。40．91％的患者可查及明确的过敏原，38．60％患者仅累及单个部位，且最常累及牙龈和唇部；临床体征多样化，主要分为红斑、红斑糜烂和增生性损害3型，病理检奄为确诊指标（吲有层密集成熟的浆细胞浸润）；目前尚无特效治疗方案，最常采用的是局部使用免疫抑制剂（应用率为40．50％），其中32．10％的病例有效。结论：原发性浆细胞性口炎是一类病因不明、少见的浆细胞浸润口腔黏膜的特殊炎症，过敏是诱因之一，特征性的牙龈红斑对疾病具有提示意义，预后一般良好，但最终转归还需观察。

Objective：To summarize and analyze the elinieal features of primary plasma cell stomatitis,amt to provide a valuable reference for the diagnosis and treatment of this disease. Method：The case reports of primalT plasma cell stomatitis were collected by using electronic bibliographic databases,paper bibliographic database,web search engines, and clinical col- lection. The effective information on clinical diagnosis was selected and statistically analyzed. Result：A total of 88 patients were included in the study including 86 patients from 43 clinical ease reports that met the inclusion criteria,and 2 patients collected by researchers in clinical treatment. The analytical results are shown： Primary plasma cell stomatitis has the maxi- mum number of cases （38 cases） in North America,with a male to female ratio of 7：15;the mean age was 43.39±18.86,the in- cidence peak existed in 21-30 group and 51-60 group;40.91% patients were found with clear allergens; the disease bit analysis showed 38.60 % patients involving a single site,mostly involving the gingiva and lips; clinical signs were diversified, mainly divided into erythema, erythema and erosion, hyperplasia lesion; the indicators were confirmed by pathological exami- nation,showing the presence of an abundant mature plasma cells infiltrating within the connective tissue;At present,there is no specific treatment method, immune-suppressive locally used tends to be the most common way. （the application rate was 40.50 % with the highest efficiency about 32.10 %）. Conclusion：Primary plasma cell stomatitis is a kind of rare oral mucosal disease of unknown etiology. Allergy is one of the triggers. The erythema on gingiva was significantly suggestive of the dis- ease;The prognosis is usually benign but the final outcome still needs observation.