结蛋白诊断早期心肌梗死的特异性研究

Study on the specificity of desmin for the diagnosis of early myocardial infarction

目的 探讨结蛋白在早期心肌梗死死后诊断的特异性。方法 应用免疫组织化学S -P法检测梗死心肌和其他非梗死性的直接或间接心肌损害的心肌结蛋白染色的变化。结果梗死心肌均可见不同程度的结蛋白缺染 ,其他非梗死性的直接或间接心肌损害的心肌中 ,如心脏挫伤、心肌炎、出血性休克、电击死、机械性窒息、有机磷中毒等 ,也有不同程度的结蛋白缺染。

Objective To explore the specificity of desmin (Dm) in the postmortem diagnosis of early myocardial infarction Methods The changes of Dm staining in the infarcted myocardium and other non-infarcted myocardium with direct or indirect myocardial injury, such as cardiac contusion, myocarditis, hemorrhagic shock, electrocution, mechanical asphyxia and organophosphate poisoning, were studied with immunohistochemical S-P method Results The loss of Dm staining in different degrees was found in the infarcted myocardium, but the change of loss of Dm staining was also seen in the other non-infarcted myocardium with direct or indirect myocardial injury, Conclusion It should be cautious to diagnose early myocardial infarction with Dm immunohistochemisrty