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诱导性CD4^+ CD25^+调节性T细胞的研究进展 被引量:1

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摘要 诱导性CD4+CD25+调节性T细胞(iTreg)是调节性T细胞的一个重要亚群,在维持机体免疫稳态和免疫相关疾病的发生发展中起重要作用。本文综述了iTreg的分子标记、外周诱导、稳定性以及与疾病的关系等相关方面的研究进展。
作者 李永菊 徐林
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2013年第12期1341-1343,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(81260398 30901318) 贵州省科技厅项目(2009C491) 贵州省国际合作项目(2010-7031)
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参考文献34

  • 1Yadav M, Louvet C, Davini D, et al. Neuropilin-I distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo[J]. J Exp Med, 2012, 209(10) : 1713 -1722.
  • 2Weiss JM, Bilate AM, Gobert M, et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3 + Treg cells[J]. J Exp Med, 2012, 209(10) : 1723 - 1742.
  • 3Thornton AM, Korty PE, Tran DQ, et al. Expression of Helios, an lkaros transcription factor family member, differentiates thymic- derived from peripherally induced Foxp3 + T regulatory cells [ J ]. J hnmunol, 2010, 184(7): 3433-3441.
  • 4Serre K, Benezech C, Desanti G, et al. Helios is associated with CIM T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression [ J/OA ]. PLoS One, 2011, 6(6) : e20731.
  • 5Akimova T, Beier UH, Wang L, et al. Helios expression is a marker of T cell activation and proliferation [ J/OA ]. PLoS One, 2011, 6 ( 8 ) : e24226.
  • 6Molinero LL, Miller ML, Evaristo C, et al. High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner[J]. J Immunol, 2011, 186(8) : 4609 -4617.
  • 7Qin A, Wen Z, Zhou Y, et al. MicroRNA-126 regulates the induction and function of CD4 + Foxp3 + regulatory T cells through PI3K/AKT pathway[J]. J Cell Mol Med, 2013, 17(2): 252 - 264.
  • 8Josefowicz SZ, Rudensky A. Control of regulatory T cell lineage commitment and maintenance [ J]. Immunity, 2009, 30 (5) : 616 - 625.
  • 9Guo Z, Khattar M, Schroder PM, et al. A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory Tcells[J]. JImmunol, 2013, 190(7): 3153 -3162.
  • 10Semple K, Nguyen A, Yu Y, et al. Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling[J]. Blood, 2011, 117( 11 ) : 3096 -3103.

同被引文献33

  • 1Sakaguchi S, Sakaguchi N, Asano M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains ( CD25 ). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases [ J ]. J Immunol, 1995, 155 ( 3 ) : 1151 -1164.
  • 2Campbell D J, Koch M A. Phenotypical and functional specialization of FOXP3 + regulatory T cells [ J ]. Nat Rev Immunol, 2011, 11(2): 119-130.
  • 3Cretney E, Kallies A, Nutt S L. Differentiation and function of Foxp3 + effector regulatory T cells [ J]. Trends Immunol, 2013, 34(2) : 74 -80.
  • 4Katoh H, Zheng P, Liu Y. Foxp3: genetic and epigenetic implications for autoimmunity[ J]. J Autoimmun, 2013, 41:72-78.
  • 5Grant C R, Liberal R, Mieli-Vergani G, et al. Regulatory T-cells in autoimmune diseases : Challenges, controversies and-yet-unanswered questions[J] Autoimmun Rev, 2015, 14(2): 105-116.
  • 6Josefowicz S Z, Lu L, Rudensky A Y. Regulatory T cells: mechanisms of differentiation and function [ J ]. Annu Rev Immunol, 2012, 30 ( 1 ) : 531 - 564.
  • 7Burzyn D, Benoist C, Mathis D. Regulatory T cells in nonlymphoid tissues[J]. Nat Immunol, 2013, 14(10): 1007-1013.
  • 8Feuerer M, Herrero L, Cipolletta D, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters[J]. Nat Med, 2009, 15(8) : 930 -939.
  • 9Tontonoz P, Spiegelman B M. Fat and beyond: the diverse biology of PPARgamma[ J]. Annu Rev Biochem, 2008, 77 : 289 - 312.
  • 10Cipolletta D, Feuerer M, Li A, et al. PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells [ J ]. Nature, 2012, 486(7404): 549-553.

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