粘附分子CD44S和CD44V_6 在胃癌中的表达

The expression of CD44 standard form and CD44 splice variant V_6 in gastric carcinoma

目的 研究粘附分子CD44S和CD44V6在胃癌中的表达。方法 采用免疫组织化学SP法对44例人胃癌组织及其27例转移淋巴结进行染色、观察。结果 CD44S和CD44V6 在胃癌原发灶中的表达率分别为36.4%(16/44)和38.6%(17/44)，且CD44S的表达与Lauren分型有关，其在弥漫型胃癌中的表达率为63.6%（7/11）明显高于肠型胃癌27.3%（9/33）（Ｐ<0.05），而CD44V6 的表达与Lauren分型无关。胃癌原发灶表达CD44S和CD44V6 者，其淋巴结转移率分别为80%(12/15)和83.3%(10/12)。结论 本实验结果提示CD44S和CD44V6 的表达与胃癌的浸润性生长和淋巴结转移密切相关。

：Objective To study the expression of CD44S and CD44V6 in gastric carcinoma. Methods 44 human surgically resected samples of primary gastric carcinoma using SP immunohistochemical staining method. Results The positive expression rates of CD44S and CD44V6 were 36.4%(16/44) and 38.6%(17/44) in primary carcinoma; in addition, there were relationships between CD44S and Lauren types of gastric carcinoma, but there were not between CD44V6 and Lauren types. When CD44S and CD44V6 expressed positively in primary site, the lymph node metastasis rates of gastric carcinoma were 80%(12/15), 83.3%(10/12) respectively. Conclusion The results suggested that CD44S and CD44V6 played major roles in invasive growth and lymph node metastasis of gastric carcinoma.