5-氟脲嘧啶及丝裂霉素对人胃癌细胞株SGc-7901的相互作用——利用中效原理体外观察

The interaction between 5-fluorouracil and mitomycin Con human gastric carcinoma cell line (SGc-7901)

目的 体外观察5-氟脲嘧啶及丝裂霉素合用对人胃癌细胞株（SGc-7901）的相互作用。方法 采用MTT法利用中效原理判定两药合用的效果。结果 两种药单独应用时随着药物剂量增加，其效应也增加；两药大剂量（大于中效剂量）合用时是协同作用（CI<1），小剂量（小于中效剂量）合用时是拮抗作用（CI>1）；两药给药时间次序不同不会影响效应大小。结论 上述两种药合用大剂量是协同小剂量拮抗，且效应大小与给药时间次序无关。

：Objective To observe the killing effects of 5-FU and MMC on human gastric carcinoma cell line (SGc-7901). Methods The median-effect principle was used. Results Killing effects of the individual drugs were enhanced as drug concentration increased. The interaction of the two drugs was synergistic at higher concentration (CI<1) and the sequence of administration did not influence the killing effects. Conclusion The interaction of the two drugs was synergistic at higher concentration (CI<1) and antagonistic at lower concentration. (CI>1).