原发性高血压与脂肪肝及血脂相关性调查

Relations between essential hypertension and fatty liver and relating parameters of laboratory tests

目的 探讨原发性高血压与血脂代谢水平及脂肪肝发生率的关系.方法 收集海南医学院附属医院原发性高血压患者351例,以及血压正常者100例,抽血检测甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、血糖、血尿酸、尿素氮和肌酐水平,B超检测脂肪肝比率,同时测量体重及体重指数.结果 高血压患者的TG、TC、AST、血糖、血尿酸、肌酐水平及脂肪肝患病率、体重和体重指数明显高于血压正常者,HDL-C低于血压正常者,差异均有统计学意义,LDL-C、ALT、尿素氮则差异无统计学意义.结论 高血压患者的脂肪肝患病率、体重及体重指数、TG、TC、AST、血糖、血尿酸、尿素氮和肌酐水平明显高于血压正常者,其与高血压呈正相关.

Objective To investigate the relations between essential hypertension and levels of TG, TC, LDL, HDL, ALT, AST, fasting glucose, uric acid, urea nitrogen, creatinine, weight and body mass index, incidence of fatty liver. Methods Data of 351 patients with essential hypertension and 100 healthy subjects with normal blood pressure were reviewed, blood pressure, presence of fatty liver, levels of TG, TC, LDL, HDL, ALT, AST, fasting glucose, blood urea nitrogen, creatinine, uric acid, body weight and body mass index were studied. Results Prevalence of fatty liver, abnormal levels of TG, TC, AST, fasting glucose, uric acid, creatinine, body weight and body mass index were significantly higher in patients with hypertension than patients with normal blood pressure; level of HDL in patients with hypertension was significantly lower than patients with normal blood pressure; and levels of LDL, ALT and urea nitrogen had no significant difference between them. Conclusion Patients with sig- nificantly higher levels of TG, TC, AST, fasting glucose, uric acid, creatinine, body weight and body mass index are more likely to develop to hypertension.