血清明胶酶与绝经后女性代谢综合征的关系

Ationship between serum gelatinase and metabolic syndrome in postmenopausal women

目的 通过测定绝经后女性代谢综合征（MS）患者血清明胶酶[基质金属蛋白酶-2（MMP-2）和基质金属蛋白酶-9（MMP-9）]水平的变化,探讨明胶酶与绝经后女性代谢综合征的关系.方法 选择2010年4月至2011年4月我院体检科、心内科及内分泌科患者,分为绝经后健康女性对照组27例及绝经后代谢综合征女性患者28例,采用酶联免疫的方法测定血清中MMP-2及MMP-9水平,用胶乳增强免疫比浊法测定血清高敏C反应蛋白（hs-CRP）水平,对两组结果进行比较分析.结果 绝经后女性代谢综合征患者血清MMP-9水平显著高于绝经后女性非代谢综合征者水平,两组比较差异有统计学意义（P＜0.01）；而两组MMP-2水平比较差异无统计学意义（P＞0.05）.结论 绝经后女性代谢综合征患者血清中可见明显高水平的MMP-9,其可能参与了动脉血管粥样硬化的早期病理生理进程.

Objective To evaluate the relationship between serum gelatinase [matrix metalloproteinase-2 （MMP-2） and matrix metalloproteinase-9 （MMP-9）] and metabolic syndrome in postmenopausal women by testingthe serum gelatinase levels of metabolic syndrome in postmenopausal women and healthy controls in postmenopausal women. Methods We collected the patients in department of physical examination, department of cardiology and department of endocrinology of our hospital from April 2010 to April 2011. And 28 patients with MS in post- menopausal women and 27 healthy controls in postmenopausal women were screened. The MMP-2 and MMP-9 lev- els in serum were detected by enzyme-linked immunosorbent assay, the level of hs-CRP were detected by latex en- hanced immunoturbidimetry,and compared and analyzed the results of two groups. Results The serum levels of MMP-9 in patients with MS in postmenopausal women was significantly higher than the controls, the differences be- tween the two groups was statistically significant （P〈0.01）, but the serum level of MMP-2 was no statistically sig- nificant difference between two groups（P〉0.05 ）. Conclusion Elevated levels of serum MMP-9 in patients with MS in postmenopansal women, the scrum MMP-9 concentration may be involved in atherosclerosis early pathophysiologi- cal process.