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SIRT1抑制炎症反应的研究进展 被引量：15

Research progress of SIRT1 in suppressing inflammatory response.
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摘要 SIRT1是在人类细胞中广泛存在的一种Sirtuin家族的组蛋白去乙酰化酶,参与了糖脂代谢、衰老等众多生理功能的调节。近年来的研究发现,在炎症反应中,SIRT1能够通过抑制多条细胞信号通路发挥抗炎作用。本文就SIRT1的生物学特性、抗炎作用及SIRT1对下游炎症信号通路的抑制作用等做一综述。 SIRT1, a histone deacetylase which belongs to the sirtuin family, is expressed in most human cells. SIRT1 plays a vital role in glucolipid metabolism and aging. There are emerging results indicating that SIRT1 can inhibit the inflammatory responses via suppressing several signaling pathways. In this review we outline recent research advances on the biological characteristics of SIRT1, its anti-inflammatory effects and its inhibition to downstream signaling pathway.
作者 曲柳 仇丽鸿
机构地区 中国医科大学口腔医学院牙体牙髓科
出处 《中国实用口腔科杂志》 CAS 2013年第9期566-570,共5页 Chinese Journal of Practical Stomatology
关键词 SIRT1 炎症反应 核因子-ΚB P38丝裂原活化蛋白激酶 SIRT1 inflammatory response NF-κB p38 MAPK
分类号 R78 [医药卫生—口腔医学]
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共引文献94

同被引文献194

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中国实用口腔科杂志
2013年 第9期

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