多形红斑与HLA相关性研究

Study on the Association Between HLA and Erythema Multiforme

目的 研究多形红斑与 HLA相关性。方法 采用血清学技术和聚合酶链式反应－序列特异性引物技术 ,检测多形红斑患者 HLAⅠ 类抗原和 HLAⅡ 类基因。结果 在 30例多形红斑患者中 ,HLA－ A30＋ 31、 B13抗原频率较对照组明显增高 (A30＋ 31：

Objective To investigate the association of erythema multiforme(EM) with HLA. Methods ClassⅠ HLA antigen was detected by serology and classⅡ HLA gene typing was performed by PCR－ SSP method, thirty patients with EM were detected. Results The frequency of HLA－ A30＋ 31 and HLA－ B13 antigen was significantly higher in EM patients than that in the controls(A30＋ 31:Pc