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CADM1、E-cad在胃癌中的表达及意义

Expression of CADM1 and E-cad in gastric carcinoma and its clinical significance
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摘要 目的探讨胃癌组织和癌旁组织中CADM1、上皮型黏附素(E-cad)的表达及意义。方法采用免疫组化SP法检测72例患者胃癌组织和24例患者癌旁组织中CADM1、E-cad蛋白的表达情况。结果 CADM1与E-cad蛋白在胃癌组织中表达阳性率明显低于癌旁组织(均P<0.05);CADM1、E-cad蛋白表达与胃癌的临床分期、浸润深度及淋巴结转移均有关(均P<0.05),而与组织学分级无关(均P>0.05);CADM1与E-cad蛋白在胃癌组织中的表达呈正相关(P<0.05)。结论 CADM1、E-cad在胃癌中的低表达或不表达,与胃癌的发生密切相关。联合检测CADM1、E-cad的表达水平,更有助于胃癌患者预后的评估及恶性程度、转移潜能的综合判断。 Objective TO investigate the expression of CADM1 and E-cad in gastric carcinoma and its clinicat significance. Methods The expressions of CADM1 and E-cad in 72 cases of gastric carcinoma and 24 samples of normal gastric mucosa were detected by immunohistochemical SP method. Results The expressions of CADM1 and E-cad proteins in gastric carcinoma tissues were significantly lower than those in normal gastric mucosa （both P〈0.05）. The expressions of CADM1 and E-cad were correlated with the clinical stage, infiltration depth and lymph mode metastasis （P〈0.05）, not correlated with histological grade. Expression of CADMlwas positively correlated with E-cad （P〈0.05）. Conclusion CADM1 and E-cad proteins are up-regulated in gastric carcinoma, which may be involved in carcinogenesis, infiltration and metastasis of gastric cancer.
作者 章辉 陶芳芳 曹学全
机构地区 台州恩泽医疗中心(集团)台州市中心医院病理科
出处 《浙江医学》 CAS 2013年第17期1568-1570,共3页 Zhejiang Medical Journal
关键词 胃癌 免疫组化 CADM1 E—cad Gastric carcinoma Immunohistochemistry CADM1 E-cad
分类号 R735.2 [医药卫生—肿瘤]
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参考文献13

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二级参考文献15

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共引文献2

浙江医学
2013年 第17期

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