钩藤生物碱对中枢神经系统的药理作用研究进展

Advances in studies on the central nervous system pharmacological effects of Uncaria alkaloids

钩藤是我国一种常用药材,对心血管系统、中枢神经系统和血液系统等均具有比较广泛的药理活性,临床上主要用于治疗高血压、焦虑等疾病。现代中药药理研究表明,钩藤对中枢神经系统的药理作用主要表现为镇静、抗癫痫、抗惊厥和对神经元的保护等,其中对神经元的保护作用与多种神经递质相关,具有多种作用机制,已被国内外越来越多的医药工作者所重视,综述钩藤生物碱对中枢神经系统的药理作用研究进展。

Uncariae Ramulus Cum Uncis is a commonly used medicinal herbs in China,which has a relatively wide range of pharmacological activity on the cardiovascular system,central nervous system,and the blood system.It is mainly used to treat hypertension,anxiety and other diseases clinically.Modern Pharmacology studies have shown that the mainly pharmacological effects of Uncaria is sedation,antiepileptic,anticonvulsant,and neuronal protection role on the central nervous system.The protective effect of neurons associated with neurotransmitters that has multifunctional action mechanism,more and more domestic and foreign medical workers have been paid attention to it,this study progress of neural pharmacological effect of rhynchophylline are described below.