郑州地区儿童流感嗜血杆菌感染的血清学研究

Serological study on acute Haemophilus influenzae infection of children in Zhengzhou area

目的 了解郑州地区儿童急性呼吸道感染 (ARI)人群中的流感嗜血杆菌 (HiB)感染状况。方法 采用酶联免疫法对 2 2 5 1例ARI(观察组 )患儿进行流感嗜血杆菌IgM (HiB -IgM)抗体测定 ,同时设 44 0例非感染病例和 2 89例健康儿童作为对照 ,并对年龄、性别、城乡和季节的感染情况进行分析。结果 观察组总阳性率为9 2 % ,非感染病例对照组阳性率为 3 2 % ,健康对照组阳性率为 3 4%。观察组与两组对照组相比差异显著 (P<0 0 1)。观察组中以～ 6个月、～ 12个月两年龄组阳性率最高 ,分别是 14 0 %和 12 5 % ,季节分布中 11月至翌年 4月的阳性率明显高于 5～ 10月 (P <0 0 1)。结论 郑州地区儿童ARI人群中HiB感染率较高 ,临床上应重视呼吸道病原学研究。

Objective\ To investigate the haemophilus influenzae(Hi)infection in children with acute respiratory tract infection(ARI)in Zhengzhou area.Methods\ IgM of Hi was detected by ELISA in 2251 children with ARI,440 non-infection cases and 289 health children.Factors related to the infection,such as age,sex,residence and season were analyzed as well.Results\ The positive rates of Hi were 9.2%,3.2% and 3.4% in ARI,non-infection and healthy groups respectively.The highest positive rates were 14.0% in ～6 months and 12.5% in ～12 months of ARI group.The positive rates on November～April was higher than that on May～October(P<0.01).Conclusion\ Hi infection rate was high in children with ARI in Zhengzhou.More attention should be paid for the pathogen study in clinical routine work.