摘要
目的 探讨一氧化氮 (NO)在小儿肾病综合征发病中的作用及中西医结合疗法对其影响。方法 采用Griess硝酸盐还原法对 32例肾病综合征进行治疗前后血清亚硝酸 /硝酸盐 (NO- 2 /NO- 3)测定 ,并以2 8例健康儿童作对照。结果 肾病组显著高于对照组 (P <0 .0 1) ,伴感染者显著高于无感染者(P <0 .0 1) ,单纯性肾病与肾炎性肾病增高程度无显著差异 (P >0 .0 5) ,治疗后随着尿蛋白阴转 ,血白蛋白、胆固醇恢复正常 ,血NO- 2 /NO- 3显著下降 (P <0 .0 1) ,与对照组比较无显著差异 (P >0 .0 5)。结论 NO参与小儿肾病综合征发病及病理损伤过程。免疫抑制剂。
Objective To find out the contribution of nitric oxide(NO) on infantile nephrotic syndrome and to observe the effect of TCM WM treatment on the serum nitric oxide level.Methods The serum nitrite/nitrate(NO - 2/NO - 3) level was determined through Griess nitrate reduction method in 32 cases of nephrotic syndrome (observe group) before and after treatment.On the other hand,28 cases of health children sa contrast (controul group).Results In the observe group,the serum NO - 2/NO - 3 level was obviously higher before therapy than that in control group and that after therapy (P<0.01) .There was not apparent difference between the observe group's level after therapy and the controul group's level (P>0.05) .There were not apparent differences between the serum NO - 2/NO - 3 level increase of the simple nephrotic syndrome infant's and one of the nephritis nephretic syndrome infant's,too (P>0.05) .Complicated by infection at acute stage was higher than that of no complicating infection in the observe group (P<0.01) .The serum NO - 2/NO - 3 level was nagative correlative with the concentration of the blood cholesterol (P<0.05) ,and was not correlative with the plasma albumin level and the uric protein quantity (P>0.05) .Conclusion Nitric oxide was contributed to pathologic damage process of infantile nephrotic syndrom.Immune suppressor and traditional Chineseherb (activating blood flow and removing blood,stasis,remitting fever and removing toxin) could be inhibit nitric oxide production and mitigate nephritic disease. [
出处
《深圳中西医结合杂志》
2000年第5期206-208,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
