胰岛素对急性血栓性脑梗死神经缺陷与认知障碍的治疗作用及其机制研究

Effects and mechanism of insulin on neurological defect and cognitive disorder in man after thrombostic cerebral infarction

目的 探讨小剂量胰岛素对急性血栓性脑梗死神经缺陷与认知障碍的治疗作用及其机制。方法 以小剂量胰岛素治疗血糖正常的急性血栓性脑梗死患者 ,一般用药组做对照 ,通过对患者治疗过程中血糖、血去甲肾上腺素 (NE)、多巴胺 (DA)、乙酰胆碱 (Ach)、P30 0 、神经缺陷评估、记忆评估的比较进行客观评价。结果 治疗组血糖变化不明显 ,DA、Ach无变化 ,NE变化有显著性。 P30 0 之 N2 、P3波潜伏期缩短、波幅增高 ,变化有显著性 ,神经缺陷康复积分显著提高 ,记忆评估改善不明显。结论 小剂量胰岛素对正常血糖的急性脑梗死患者运动、感觉、认知障碍有治疗作用 ,对记忆障碍改善无显著性。

Objective To study the effects and mechanism of insulin on neurological defect and cognitive disorber in man after acute thrombostic cerebral infarction(ATCI). Methods To assess the effects of insulin on ATCI by comparing the changes of plasma glucose,NE,DA,Ach,P 300 ,Neurologic score and Memory assessment score. Results There were no different between trial and control group in plasma glucose,DA,Ach and memory assessment score. but the variance of NE was notable. The potential period of N 2,P 3 Waves of P 300 were reduced significantly while its width elevated significantly also. Conclusion Small doses of insulin can treat and ameliorate ATCI patients , motor,sensory cognitive disorder,but the memory elevated a little.