氯仿/甲醇处理同种异体肌腱移植的生物力学变化

Biomechanical study of transplantation of allograft tendon treated by CM

目的 :探讨氯仿 /甲醇 (CM)处理的同种异体肌腱移植后的生物力学性质。方法 :2 4只新西兰兔随机选择 1侧跟腱行CM腱移植 ,另一侧行自体移植。按术后 1、2、6、12周行生物力学测试。结果 :自体腱移植组和CM肌腱移植组的拉伸强度和刚度在术后 1、2周 ,6周与术前、术后 12周分别有显著性差异(P <0 .0 1)。自体腱移植组与CM腱移植组术后 12周的拉伸强度和刚度无显著性差异 (P >0 .0 5 )。结论 :CM腱移植组与自体腱移植组在各个时间点的力学变化相近 ,无统计学变异 ,可以用来替代自体腱。

Objective:To explore the biomechanical characters of transplantaion of allograft tendon treated by Chlorofom/Methanol(CM).Methods:Achilles tendon transplantation was performed on twenty four New Zealand white rabbits.One side was randomly selected to perform autograft tendon transplantation and the other side was perform allograft CM tendon transplantation.Biomechanical tests were made on week 1,week 2,week 6 and week 12 weeks after transplantation.respectively.Results:There strength and stiffness existed remarkable significance between on week 12 after transplantation and on week 1, week 2, week 6 after transplantation( P <0.01) in autograft group.So did allograft group.The strength had no difference between CM tendon group and augraft tendon group 12 weeks after transplantation( P >0.05).Conclusion:As CM tendon had the similar biomechanical characters with autograft tendon after transplantation at various period,it could be used as an alternative tendon during tendon transplantation.