老年男性阻塞性睡眠呼吸暂停程度与代谢综合征的相关性研究

Study of correlation between obstructive sleep apnea syndrome and metabolic syndrome in the male elderly

目的:研究老年男性阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)严重程度与代谢综合征的相关性。方法:随机选择我院收治的663例老年患者,根据呼吸暂停及低通气指数,将其分为非OSAS组和轻、中、重度OSAS组。比较各组患者颈围、体质指数(BMI)、腰臀比、血压、血脂、空腹血糖等,分析OSAS严重程度与代谢综合征及其组分发病率之间的相关性。结果 OSAS患者的颈围、BMI、腰臀比、收缩压、舒张压、空腹血糖等显著高于非OSAS组患者。OSAS严重程度与颈围、BMI、甘油三酯等存在显著正相关,且随着OSAS严重程度的增加,代谢综合征及其组分的发生率呈逐渐递增趋势。结论:老年男性阻塞性睡眠呼吸暂停程度与代谢综合征发病率密切相关,这可能是阻塞性睡眠呼吸暂停综合征增加心血管疾病发生率和死亡率的主要原因。

Objective ：To study the correlation between the degree of obstructive sleep apnea syndrome and metabolic syndrome in the male elderly .Methods 663 male elderly over 60 years old were enrolled in the study randomly .They were divided into four groups according to apnea -hypopnea index ：non-OSAS group and mild ,moderate and severe OSAS group .Data were analyzed ,including neck circumference ,body mass index （BMI） ,waist-to -hip ratio （WHR） , blood pressure ,blood lipids ,fasting blood glucose（FPG） ,and so on .Spearman correlation analysis was used to explore the relationship between severity of OSAS and the incidence of metabolic syndrome and its components .Results OSAS group were significantly higher than non -OSAS group in neck circumference ,BMI , WHR ,systolic blood pressure （SBP） ,diastolic blood pressure （DBP） and FPG .There were significant positive correlation between severity of OSAS and neck circumference ,BMI and TG .Incidence of MS and its components were gradually increasing with the aggravation of OSAS severity .Conclusion There was closely relationship between OSAS severity and incidence of MS in older men ,which may increase the incidence and mortality of cardiovascular disease .