三消汤治疗肝硬化腹水的临床方案研究

Research of Clinical Programs about Sanxiao Decoction on Liver Cirrhosis with Ascites

目的:探索三消汤治疗肝硬化腹水的最佳临床方案。方法:120例患者随机分为对照组、试验1组和试验2组。对照组予西药,试验1组予三消汤,试验2组予三消汤+西药。疗程15 d,随访6个月。比较3组临床疗效、症状评分及6个月后腹水复发和死亡情况。结果:治疗15 d后,3组临床疗效差异有意义(P<0.01);腹胀、乏力、水肿评分改善有意义(P<0.05),纳差、小便短少评分改善无意义(P>0.05)。随访6个月,3组腹水复发率差异有意义(P<0.01),死亡率差异无意义(P>0.05)。结论:西医、中医和中西医结合3种方案相比,中西医结合在改善症状、促进腹水消退及减少复发等方面优于其他方案;但在降低死亡率方面,3种方案并无差别。

Objective：To explore the best clinical program of Sanxiao Decoction on liver cirrhosis with ascites. Methods： 120 patients of ascites due to liver cirrhosis were randomly divided into three groups （ control group, test group 1, test group 2 ）. The control group was treated with western medicine;the test group 1 was treated with Sanxiao Decoction;the test group 2 was treated with both western medicine and Sanxiao Decoction. The period of treatment was 15 days, following up for 6 months. The three groups were compared with the clinical effects, symptom scores,relapses of aseites and mortalities after 6 months. Results：After 15 days,the difference of clinical effects in three groups were significant （P 〈 0.01 ） ;the changes of symptom scores in the abdomen distention, asthenia and edema were significant （ P 〈 0.05 ） , while the poor appetite and urine negative were not significant （ P 〉 0. 05 ）. After 6 months, the difference in the rate of ascites relapses was significant （ P 〈 0.01 ） , and the difference in the mortality rate was not significant （ P .〉 O..05 ）. Conclusion ： Compared with the three clinical programs of western medicine, TCM and the combination of TCM and western medicine, the clinical program of the combination of TCM and western medicine is superior to others in mitigating symptoms, accelerating ascites disappearing and reducing the rate of aseites relapses, while there is no differ- ence in lowering the mortality rate.